Drug-Loaded Chondroitin Sulfate Microspheres Generated from Microfluidic Electrospray for Wound Healing

Hongzhen Zhang; Ronghua Xu; Zuowen Yin; Jun Yu; Ning Liang; Qian Geng

Macromolecular Research, Vol.30, No.1, 36-42, January, 2022

DOI10.1007/s13233-022-0001-4 Export Citation

Drug-Loaded Chondroitin Sulfate Microspheres Generated from Microfluidic Electrospray for Wound Healing

Hongzhen Zhang, Ronghua Xu, Zuowen Yin, Jun Yu, Ning Liang^{1, †}, and Qian Geng^{2, †}

Gastrointestinal surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518052, P. R. China
¹Department of Dermatology, The Affiliated Changzhou No.2 People’s Hospital with Nanjing Medical University, Changzhou, 213000, P. R. China
²Emergency department, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518052, P. R. China

E-mail:,

Wound treatment is an important issue and poses a critical challenge for healthcare systems. It is of great significance to develop materials for wound repair and regeneration. Herein, we presented a kind of novel drug-loaded methacryloyl chondroitin sulfate (CSMA) microspheres for promoting the wound healing process. The CSMA droplets were generated from microfluidic electrospray and polymerized with ultraviolet light. With further freeze-drying and drug uploading, the drug-loaded CSMA microspheres were achieved. The prepared microspheres exhibited excellent biocompatibility, and the following animal experiments indicated they could promote wound healing significantly. This study opens the door to drug-loaded CSMA microspheres for wound healing applications.

Keywords:drug-loading;chondroitin sulfate;microspheres;microfluidic electrospray;wound healing

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[3] Grainger DW, Nat. Mater., 14(7), 662 (2015)

[4] Sun BK, Siprashvili Z, Khavari PA, Science, 346(6212), 941 (2014)

[5] Yang X, Yang J, Wang L, Ran B, Jia Y, Zhang L, Yang G, Shao H, Jiang X, ACS Nano, 11, 5737 (2017)

[6] Liang N, Wu L, Yang Y, Mater. Express, 11, 1084 (2021)

[7] Zhang ZY, Sun Y, Zheng YD, He W, Yang YY, Xie YJ, Feng ZX, Qiao K, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 106, 110249 (2020)

[8] Lei L, Zhu Y, Qin X, Chai S, Liu G, Su W, Lv Q, Li D, Chem. Eng. J., 425, 130671 (2021)

[9] Fan M, Ma Y, Tan H, Jia Y, Zou S, Guo S, Zhao M, Huang H, Ling Z, Chen Y, Hu X, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 71, 67 (2017)

[10] Yang Z, Huang R, Zheng B, Guo W, Li C, He W, Wei Y, Du Y, Wang H, Wu D, Wang H, Adv. Sci., 8, 200362 (2021)

[11] Cheng X, Li M, Wang H, Cheng Y, Chinese Chem. Lett., 31, 869 (2020)

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[15] Bai X, Lu S, Cao Z, Ni B, Wang X, Ning P, Ma D, Wei H, Liu M, Carbohydr. Polym., 166, 123 (2017)

[16] Wang H, Zhao Z, Liu YX, Shao CM, Bian FK, Zhao YJ, Sci. Adv., 4, eaat28 (2018)

[17] Zhao C, Chen G, Wang H, Zhao Y, Chai R, Bioact. Mater., 6, 1653 (2021)

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[19] Liao J, Shi K, Jia Y, Wu Y, Qian Z, Bioact. Mater., 6, 2221 (2021)

[20] Guan J, Yuan FZ, Mao ZM, Zhu HL, Lin L, Chen HH, Yu JK, Polymers, 13, 2146 (2021)

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[33] Martin P, Science, 276(5309), 75 (1997)

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