화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.46, No.2, 145-158, March, 2022
DOI10.7317/pk.2022.46.2.145  Export Citation
품질관리 향상을 위한 다양한 생체고분자의 영향과 동결건조 부유약제의 특성 분석
Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters
Rukiye Sevinc Ozakar, and Emrah Ozakar†
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
E-mail:
Conventional oral drug systems are unable to keep drug concentration within the therapeutic range, and administration of the dosage form several times a day can cause significant fluctuations in plasma drug concentration. Therefore, floating drug delivery systems are being developed. In this study, floating tablets with a model drug (ampicillin sodiumAmp.Na) were successfully prepared using different polymers by the lyophilization technique. This study aims to prepare and characterize floating lyophilized tablets to understand the effect of different biopolymers on quality control parameters more clearly. Within the scope of characterization studies, many parameters were evaluated successfully. All tablets showed 24-hour release and had a mesoporous structure, as understood from the Brunauer-Emmett-Teller (BET) analysis. It has been determined from the Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses that Amp.Na doesn’t interact with excipients and is an amorphous form. These formulations can be used for other drugs in the future, and optimum properties can be easily characterized.
Keywords:floating tablet;lyophilization;polymers;release kinetics;Brunauer-Emmett-Teller;Fourier transform infrared;X-ray diffraction
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