화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.109, 221-229, May, 2022
DOI10.1016/j.jiec.2022.02.003  Export Citation
Synthesis and drug release behavior of functional montelukast imprinted inulin-based biomaterials as asthma treatment
Kyeong-Jung Kim, Min-Jin Hwang1, Yeon-Hum Yun2, †, and Soon-Do Yoon†
  • Department of Biomolecular and Chemical Engineering, Chonnam National University, Jeonnam 59626, South Korea
  • 1Department of Environmental System Engineering, Chonnam National University, Jeonnam 59626, South Korea
  • 2Department of Energy & Resources Engineering, Chonnam National University, Gwangju 61186, Republic of Korea
E-mail:,
In this study, functional montelukast (MTL) imprinted biomaterials were prepared using inulin (INL), polyvinyl alcohol (PVA), MTL, sunset yellow FCF (SY) as a light stabilizer, plasticizers, and press needle (PN). INL-based biomaterials were synthesized with a casting method followed by heat curing. MTL and biomaterials were characterized by FE-SEM, FT-IR, and 1H NMR. In addition, MTL release properties on MTL imprinted biomaterials were examined at pH 5.5 at various temperatures. Results showed that MTL release (%) of SY added biomaterials was increased by 1.97 times compared to those of MTL imprinted biomaterials without the addition of SY. This might be because SY, a light stabilizer, could inhibit the degradation of MTL by light. Results of MTL release using artificial skin verified that MTL was released sustainably for 12 h. We further confirmed that MTL release at pH 5.5 at various temperatures followed the pseudo-Fickian diffusion mechanism, whereas MTL release using artificial skin followed the non-Fickian diffusion mechanism.
Keywords:Functional INL-based biomaterial;Montelukast;Drug release mechanism
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