Recently, the fluidized bed has been shown to assist in improving the recovery of coarse minerals during flotation. In this study, the fluidization characteristics of spherical and irregular particles in a three-dimensional liquidsolid fluidized bed were studied by combining experimental and computational fluid dynamics (CFD) methods. Fluidization experiments were performed to investigate the effect of superficial velocity, particle shape, and particle size on solid holdup and bed expansion height. CFD model coupled different drag models for spherical and irregular particles were developed and validated by the experimental data of bed expansion ratio and pressure drop. Based on 3D CFD simulations, the axial and radial direction distributions of solid holdup, axial velocity, as well as granular temperature were obtained. Their distribution characteristics were analyzed and discussed in detail. The reported experimental data and simulation results can improve the understanding of irregular granular liquid-solid fluidized bed and provide a basis for further research on fluidized bed flotation.