Controlled-release behavior of nicotine from chitosan microparticles coated with two artificial lipids was investigated. These lipid coating chitosan microparticles can control the release rate of nicotine under zero-order kinetics for a long period as well as a wide range of release extents. Additionally, the release rates of nicotine significantly increased beyond 34 similar to 37 degrees C, possibly due to the phase transition phenomena of artificial lipid coatings. These lipid coating chitosan microparticles may be applied to transdermal nicotine patches for controlled-release as well as long preservation period.