A chemical heat pipe system using the endothermic heat of mixing of solid-liquid (s-l) or liquid-liquid (l-l) mixable materials seems very attractive for cold heat generation and accordingly, evaluation of the most suitable mixing-pairs in terms of cold heat capacity is carried out. In s-l pairs, urea/water and ammonium nitrate/water are found to generate large amount of endothermic heat, about 8.16 kW.kg(-1), as soon as the materials are mixed. Similarly, irrespective of the initial temperature, isobutanol/acetonitrile and 1-butanol/acetonitrile are found to produce cold heat of about 0.841 kW.kg(-1). For regeneration, drying and distillation processes are reviewed for s-l and l-l systems, respectively, and it is found that heat at 353 K can be used for regeneration. As a result, the authors propose a heat pipe system using low level waste heat energy for cold heat generation based on the endothermic heat of mixing.