In the case of a chemical reaction followed by precipitation in a semibatch reactor, there are possibilities that no precipitate deposits because the concentration of chemical reaction product does not exceed its solubility, and the coprecipitation or adsorption of impurities contaminates the precipitate as the concentration of reaction product becomes too high temporarily. Proper operation to keep the state in a semibatch reactor suitable for precipitation is established with isocline analysis on the phase plane, as follows: (1) The flow rate of feed is increased with time exponentially so that the concentrations of reactant and reaction product in a semibatch reactor have a pseudo-steady state. (2) The concentration of reactant in feed, which keeps the concentration of reaction product at a pseudo-steady state over its solubility can be calculated from an isocline equation. (3) If the concentration of reactant in the reactor at the beginning of the operation is not higher than that of the pseudo-steady state, then the concentration of reaction product approaches the pseudo-steady state with time monotonously, not going beyond the pseudo-steady state.