The development of blood compatible materials has evolved through the understanding of the importance of modulus matching of the implants material with human tissue, through surface chemistry adaptation to tissue engineering. Analytical techniques involving labeling and spectroscopy have led to a better understanding of protein adsorption behavior which is considered as the initial event for trombos formation. Significant success in prolonging in vivo times for implants has been the result However the complexity of the human defense system and of human body parts still prevents us from making totally blood compatible implants.