The elimination of specific oxygenated groups of biomass-derived pyrolysis oils (bio-oils) is necessary for improving their stability. These are mainly unsaturated groups like alkene, carbonyl and carboxylic functions, as well as guaiacyl groups. For practical applications, it is desirable that the reactions are performed selectively in order to avoid excessive hydrogen consumption. The reactions must be done at relatively low temperature in order to limit competitive thermal condensation reactions. In this study, model oxygenated compounds were used, namely 4-methylacetophenone, diethyldecanedioate and guaiacol. They were tested simultaneously in one reaction test in the presence of sulfided cobalt-molybdenum and nickel-molybdenum supported on gamma-alumina catalysts in a batch system. Their reactivity and conversion scheme were determined. The ketonic group is easily and selectively hydrogenated into a methylene group at temperatures higher than 200 degrees C. Carboxylic groups are also hydrogenated to methyl groups, but a parallel decarboxylation occurs at comparable rates. A temperature around 300 degrees C is required for the conversion of carboxylic groups as well as for the conversion of the guaiacyl groups. The main reaction scheme of guaiacol is its transformation in hydroxyphenol which is subsequently converted to phenol. But in batch reactor conditions, guaiacol gives a high proportion of heavy products. CoMo and NiMo catalysts have comparable activities and selectivities. However, the NiMo catalyst has a higher decarboxylating activity than CoMo and also leads to a higher proportion of heavy products during the conversion of guaiacol.