The organic crystals of tri-O-methyl-beta-cyclodextrin (TMCD) and its three clathrate compounds containing benzoic acid (BA), p-nitrobenzoic acid (NBA) and p-hydroxybenzoic acid (HBA), sucrose (SUC), salicin (SAL), phenolphthalein (PP), 1,3,5-tri-alpha-naphthylbenzene (TNB) were amorphized by grinding with a vibrating mill for 2-16 h at room temperature. The amorphization was checked by differential scanning calorimetry (DSC) and X-ray powder diffraction. The. heat capacities of crystals, liquid quenched glasses (LQG), and ground amorphous solids (GAS) of TMCD and TNB were measured with an adiabatic calorimeter in the temperature range between 12 and 375 K. For both compounds, the enthalpy relaxation of GAS followed quite unusual temperature evolution and the released configurational enthalpy was much larger than that of LQG, indicating that GAS is more disordered and strained than LQG. The grinding-time and grinding-temperature dependences on the enthalpy relaxation were also investigated for TMCD. It was found that the latter effect is more important than the former.