Applied Microbiology and Biotechnology, Vol.42, No.2-3, 385-390, 1994
Antifungal Activity of Cysteine, Its Effect on C-21 Oxygenated Lanosterol Derivatives and Other Lipids in Inonotus-Obliquus, in-Vitro
The antifungal activity of cysteine (2-amino-3-mercaptopropionic acid) on mycelial growth and the production of lanosterol, 3,beta-hydroxy-lanosta-8,24-dien-21-al, 3,beta-21,dihydroxy-lanosta-8,24-diene, trametenolic acid and ergosterol were investigated in solid and liquid cultures of Inonotus obliquus at cysteine concentrations of 0.9 and 9.0 mM by means of thin-layer chromatography densitometry. Cysteine elicited the production of ergosterol in all the cultures and at a concentration of 0.9 mM distinctly elicited the production of 3,beta-hydroxy-lanosta-8,24-dien-21-al. At 9.0 mM, cysteine had greater antifungal activity than at 0.9 mM, decreasing growth and the production of metabolities.