End-capped fluoroalkyl segments in 2-acrylamido-2-methylpropanesulfonic acid oligomers could serve as a new interaction for gelation in both water and organic polar solvents under non-cross-linked conditions, and these gelling oligomers were found to be selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replication, suggesting that the compounds have the potential to prevent HIV-I transmission through their chemical and biological properties.