Polymer Bulletin, Vol.40, No.2-3, 151-157, 1998
Self-assembling functionalized templates in biosensor technology
A bifacial topological template exhibiting metal-binding sites and thioalkane chains has been incorporated into self-assembled monolayers and immobilised on gold surfaces : These systems allow for the detection of external ligands by SPR spectroscopy representing a first step in developing biosensors based on the TASP (Template Assembled Synthetic Proteins) concept.
Keywords:SOLID-PHASE SYNTHESIS;TOTAL CHEMICAL SYNTHESIS;SURFACE-PLASMON;RECOGNITION REACTIONS;CYCLIC-PEPTIDES;PROTEIN DESIGN;NOVO DESIGN;MONOLAYERS;BINDING;OPTIMIZATION