In this paper, we report the results of the study of the first model of solar photovoltaic refrigerator with three compartments: one for vaccine and medicines storage, the second one for the personal use of the medical staff, and the third one for water freezing. A cold storage is made around the evaporator in order to give the system several days of autonomy. The experimental study of the system has been made, as well as a dimensionment of the photovoltaic generator. The main results are the following: the power of the P.V. generator is 350 w peak the value of the thermal loss is 11 w at a steady rate, the mean temperatures are the following: vaccine compartment: 4 degrees C medical staff compartment: 5 degrees C the autonomy of the system due to the cold storage is about three days. the capacity of the battery used is 150 Ah. Different correlations have been established between the characteristic parameters of the system, including the mass of ice used for the cold storage. The thermodynamic study of the refrigerator is realized with a particular emphasis on exergetic analysis. We found an exergetic efficiency of 17%. Finally, the performances of the refrigerator are compared to those studied by other researchers.