Electric Power Research Institute (EPRI) and the LIS Department of Energy (DOE) have been funding a number of case studies under the initiative entitled "Economic Development through Biomass Systems Integration", with the objective of investigate the feasibility of integrated biomass energy systems, utilizing a dedicated feedstock supply system (DFSS) for energy production. This paper deals with the full fuel cycle for four of these case studies, which have been examined with regard to the emissions of carbon dioxide, CO2. Although the conversion of biomass to electricity in itself does not emit more CO2 than is captured by the biomass through photosynthesis, there will be some CO2 emissions from the DFSS. External energy is required for the production and transportation of the biomass feedstock, and this energy is mainly based on fossil fuels. By using this input energy, CO2 and other greenhouse gases are emitted. However, by utilizing biomass with fossil fuels as external input fuels, we would get about 10-15 times more electric energy per unit fossil fuel, compared with a 100% coal power system. By introducing a DFSS on former farmland the amount of energy spent for production of crops can be reduced, the amount of fertilizers can be decreased, the soil can be improved and a significant amount of energy will be produced compared with an ordinary farm crop. Compared with traditional coal-based electricity production, the CO2 emissions are in most cases reduced significantly by as much as 95%. The important conclusion is the great potential for reducing greenhouse gas emissions through the offset of coal by biomass.