The dissolution enthalpies of urea in aqueous solutions of 2-methoxyethanol and 2-butoxyethanol have been measured and the relevant enthalpic pair interaction coefficients h(xy)(urea-non-electrolyte) in water have been determined. These results, in conjunction with the data concerning urea-non-electrolyte pairs taken from our earlier reports and from the literature, were analysed with respect to the effect of non-electrolyte hydration on variations of the h(xy) values in water. The coefficients for urea-non-electrolyte systems are linearly correlated with the heat capacity of interaction of the non-electrolyte with solvent water.