The melting point depression in the mixtures of acetamide-zinc acetate dihydrate was measured by DSC in the concentration range 0-0.331 mole fraction of zinc acetate dihydrate. Two sets of measurements were obtained for the two crystalline forms with different melting points in which the melts crystallized. Eutectic mixtures also appeared in both crystalline forms. From the experimental melting point depression data and relevant thermodynamic parameters of pure acetamide, activity coefficients of both components were calculated. The results obtained for the two sets of measurements agreed within +/- 5%. The Van’t Hoff dissociation parameter was also calculated in the concentration range studied.