The enthalpies of solution of 12-crown-4, 15-crown-5, 18-crown-6 and 1,10-diaza-18-crown-6 in aqueous D-glucose, were determined experimentally. The cross coefficients of the virial expansion of the excess enthalpies were calculated. On the basis of experimental density data, the limiting partial molar volumes of transfer of crown ethers from water to 1 m aqueous D-glucose solution were also evaluated. It is shown that the interactions between crown ethers and D-glucose are weak, but that the endothermic effect of these interactions decreases with an increase in the size of the crown ether macrocycle.