Recent developments have led to a general procedure that allows the analysis of isothermal microcalorimetric data to determine both kinetic and thermodynamic information. Such an analysis means that isothermal microcalorimetry is a powerful technique with which to gain information on a wide range of reactions. Previously, the method of analysis has, principally, been applied to simple, two-stare, solution phase reactions. It is the purpose of the data presented here to show how such an analysis may be applied to solution phase reactions that follow more complex, consecutive reaction pathways using, as a model and example, the acid catalyzed hydrolysis of potassium hydroxylamine trisulfonate.