가교된 폴리(N-이소프로필아크릴아마이드)겔의 팽윤성에 대한 pH 및 혼합용매의 영향

김수연; 김용주; 성용길

Polymer(Korea), Vol.15, No.5, 531-538, October, 1991

Export Citation

가교된 폴리(N-이소프로필아크릴아마이드)겔의 팽윤성에 대한 pH 및 혼합용매의 영향

Effects of pH and Mixed Solvents on Swelling Properties of Crosslinked Poly(N-isopropyl acrylamide) Gels

김수연, 김용주, 성용길

초록

폴리(N-이소프로필 아크릴아마이드-에틸렌글리콜 디메타클레이트)[P(NIPAAm-EGDMA)] 및 폴리(N-이소프로필 아크릴아마이드-디비닐벤젠)[P(NIPAAm-DVB)]의 팽윤전이현상이 각각 30℃와 25℃ 근처에서 일어났다. 또한 가교된 P(NIPAAm-EGDMA) 수화겔은 30℃ 근처에서 흡열피이크를 보이고, 가교된 P(NIPAAm-DVB) 수화겔은 25℃ 근처에서 각각 흡열피이크가 나타났다. 1,4-디옥산과 물의 혼합용액에서 가교된 P(NIPAAm-EGDMA)와 P(NIPAAm-DVB)의 팽윤도는 1,4-디옥산이 85%(V/V)되는 근처에서 최대값이 나타났다. pH가 조절된 완충용액에 대한 가교된 P(NIPAAm-EGDMA)의 팽윤도는 pH 7.5 근처에서 최소값을 가지나 가교된 P(NIPAAm-DVB)의 팽윤도는 거의 변하지 않았다.

The swelling transition phenomena of poly(N-isopropyl acrylamide-ethylene glycol dimethacrylate)[P(NIPAAm-EGDMA)] and poly(N-isopropyl acrylamide-divinyl benzene)[P(NIPAAm-DVB)] occurred near 30℃ and 25℃, respectively. Crosslinked P(NIPAAm-EGDMA) and P(NIPAAm-DVB) hydrogels also exhibited endothermic peaks near 30℃ and 25℃, respectively. The swelling degrees of the crosslinked P(NIPAAm-EGDMA) in the mixture of 1,4-dioxane and water had maximum values near 85%(V/V) of 1,4-dioxane in the mixture. The swelling degree of the crosslinked P(NIPAAm-EGDMA) in the pH controlled buffer solution had minimum value near pH 7.5 but that of crosslinked P(NIPAAm-DVB) did not change nearly.

[References]

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[1] Dong LC, Hoffman AS, J. Control. Release, 4, 223 (1986)

[2] Chiklis CK, Grasshoff JM, J. Polym. Sci. A: Polym. Chem., 8, 1617 (1970)

[3] Eliassaf J, J. Appl. Polym. Sci., 22, 873 (1978)

[4] Hirokawa Y, Tanaka T, J. Chem. Phys., 81, 6379 (1984)

[5] Katayama S, Hirokawa Y, Tanaka T, Macromolecules, 17, 2641 (1941)

[6] Hoffman AS, Dong LC, J. Control. Release, 4, 213 (1986)

[7] Park TG, Hoffman AS, IUPAC Polymer Symposium Preprints, p. 263 (1989)

[8] Yang HJ, Hoffman AS, IUPAC Polymer Symposium Preprints, p. 265 (1989)

[9] Khokhlov AR, Polymer, 21, 376 (1980)

[10] Daoud M, Bouchaud E, Macromolecules, 19, 1955 (1986)

[11] Dusek K, Patterson D, J. Polym. Sci. A: Polym. Chem., 6, 1209 (1968)

[12] Flory PJ, "Principle of Polymer Chemistry," Ithaca, New York (1953)

[13] Alfrey T, Lloyd WG, J. Polym. Sci., 62, 159 (1962)

[14] Hosaka S, Yamada A, Tanzawa H, Momose T, J. Biomed. Mater. Res., 14, 557 (1980)

[15] Winsniewski SJ, Ph.D. Dissertation, The University of Utah, Utah, U.S.A. (1970)

[16] Tanaka T, Polymer, 20, 1404 (1979)

[17] Domb C, Polymer, 15, 259 (1974)

[18] Ilavsky M, Hroz J, Macromolecules, 17, 2868 (1984)

[19] Ilavsky M, Macromolecules, 15, 782 (1982)

[20] Peppas NA, "Hydrogel in Medicine and Pharmacy," CRC, Vol. 1, p. 28 (1986)