천연 다당류 연고의 Rat 피부에 대한 화상치유 효과

황성규; 김용렬; 이한섭; 배지선; 김대용; Sung Kwy Hwang; Yong Yeul Kim; Han Seob Lee; Ji Seon Bae; Dae Yong Kim

Journal of the Korean Industrial and Engineering Chemistry, Vol.11, No.6, 657-661, October, 2000

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천연 다당류 연고의 Rat 피부에 대한 화상치유 효과

Burn Remedial Effects on Rat Skins of Natural Polysaccharide Ointments

황성규^†, 김용렬 ¹, 이한섭², 배지선³, 김대용³

명지대학교 세라믹화학공학부, 용인 449-728
¹대진대학교 화학공학과, 경기 487-800
²용인대학교 환경보건학과, 용인 449-714
³서울대학교 수의과대학, 서울 151-742

Sung Kwy Hwang^†, Yong Yeul Kim¹, Han Seob Lee², Ji Seon Bae³, and Dae Yong Kim³

Division of Ceramic Chemical Engineering, Myong Ji University, Yongin 449-728, Korea
¹Department of Chemical Engineering, Daejin University, Kyunggi 487-800, Korea
²Department of Environmental Health, Yong In University, Youngin 449-714, Korea
³epartment of Veterinary Pathology, School of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea

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초록

천연 고분자를 이용하여 화상연고를 제조하고 이를 인위적 화상을 입힌 rat의 피부에 적용하여 치료기간에 따른 혈액학적, 피부병리조직학적 평가를 실시하여 이에 대한 화상치유 효과를 조사하였다. 천연 다당류를 이용하여 제조한 화상연고는 새로운 조직 재생성과 염증감소 효과를 나타내었으며 본 연구를 통하여 천연 다당류로부터 제조한 화상연고는 기존 연고와 비교하여 화상치료에 보다 더 효과적이었음을 확인할 수 있었다.

We prepared burn ointments which were mainly consisted of natural polysaccharide. This burn ointments were applied on the rat's skin which was wounded by artificial burns. Their effects on the healing properties were investigated by the evaluation of histological and hematological change as a function of time. The results showed that the burn ointments made from natural polysaccharide were effective in formation of the new tissue and reduction of inflammation. It was discovered that the new ointments were more effective in the healing the burnt wounds than the existing ointment substitutes.

Keywords:Rat;Ointment;Burn remedial effect;Hematological;Histological

[References]

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서울대 의과대학 약리학교실, 약리학, 고려의학, 서울, 814 (1994)
박선섭, 유일준, 피부작용약, 정문각, 서울, 253 (1998)
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William J, Linda M, "Color Atlas of Veterinary Histology," ch. 2, 1st ed., Williams & Wilins, Hong Kong, 53 (1990)
Mitruka B, Rawnsley H, "Clinical Biochemical and Hematological Reference Values Normal Experimental Animals and Normal Humans," 2nd ed., MASSON Publishing, New York, 58 (1981)
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[Related Articles]

[1] Hagino Y, Huang S, In Proceedings of ACS Division of Polymeric Materials: Sci. Eng., 72, 249 (1995)

[2] Day D, Ashby R, In Proceedings of ACS Division of Polymeric Materials: Sci. Eng., 72, 141 (1995)

[3] Matthew IR, Browne RM, Frame JW, Millar BM, Biomaterials, 16, 265 (1995)

[4] Barnett SE, Varley SJ, Annu. R. Coll. Surg. Engl., 69, 153 (1987)

[5] Seth S, Lawrence E, Biochem., 29(36), 8199 (1990)

[6] Keij S, Masami W, Biochem. Biophys. Res. Com., 186, 1257 (1992)

[7] 서울대 의과대학 약리학교실, 약리학, 고려의학, 서울, 814 (1994)

[8] 박선섭, 유일준, 피부작용약, 정문각, 서울, 253 (1998)

[9] Cocabo S, Bromilow D, Topical Antiinfectives, KIMS, MIMS, 8(3), 281 (1994)

[10] Yi S, Jang D, Ahn R, Korean J. Toxicol., 13(1), 79 (1997)

[11] Edna B, Bob M, Leslie H, "Laboratory Methods in Histotechnology," 1st ed., Armed Forces Institute of Pathology, Washington, 1 (1994)

[12] William J, Linda M, "Color Atlas of Veterinary Histology," ch. 2, 1st ed., Williams & Wilins, Hong Kong, 53 (1990)

[13] Mitruka B, Rawnsley H, "Clinical Biochemical and Hematological Reference Values Normal Experimental Animals and Normal Humans," 2nd ed., MASSON Publishing, New York, 58 (1981)

[14] Baker H, Lindsey J, Weibroth S, The Laboratory Rat, Academic Press, New York, 21 (1979)

[15] Nakeye M, Ueki H, Jpn. J. Dermatol., 8, 187 (1981)

[16] Kumagai N, "Clinical Application of Autologous Cultured Epithelia for the Treatment of Burn Wounds and Burn Scars," Advances in Wound Dressing and Cultured Skin Substitute, Wound Healing Center Kitasato University Hospital, 162 (1994)