불소화된 풀리우레탄의 기계적 물성과 혈소판 점착특성에 관한 연구

김형중; Hyung-Joong Kim

Polymer(Korea), Vol.25, No.3, 343-348, May, 2001

Export Citation

불소화된 풀리우레탄의 기계적 물성과 혈소판 점착특성에 관한 연구

A Study for Mechanical and Platelet Adhesion Properties of Fluorinated Polyurethanes

김형중^†

공주대학교 공과대학 신소재공학부

Hyung-Joong Kim^†

Division of Advanced Material Engineering, College of Engineering, Kongju National University, Chungnam, Kongju 314-701, Korea

E-mail:

초록

Perfluorinated polyether diol (Fomblin ZDOL(ⓡ))과 4,4'-diphenyl methane diisocyanate (MDI)로부터 합성된 불소화된 폴리우레탄 탄성체의 기계적 성질과 혈소판 점착 특성을 연구하였다. Fomblin 함량과 혼합 사용된 polyether polyol의 종류에 따른 기계적 성질의 검토를 인장실험 및 dynamic mechanical analysis를 통해 행하였다. 또한 혈소판 점착실험을 통해 불소화된 폴리우레탄 탄성체의 혈액적합성을 평가하였다. 기계적 물성은 혼합된 polyether polyol의 종류와 함량에 영향을 받았고, 혈소판 점착은 모든 불소화된 폴리우레탄에서 불소화 함량의 증가에 따라 감소하였다.

The mechanical and the platelet adhesion properties of the fluorinated polyurethane elastomers synthesized with a perfluorinated polyether diol (Fomblin ZDOL((R))) and 4,4'-diphenyl methane diisocyanate (MDI) were investigated. The change of mechanical properties with the Fomblin content and the type of the polyether diol was investigated by applying a designed technique using in vitro platelet adhesion test. As a result, the tensile properties were affected by the content and the type of mixed polyether diols. Also the platelet adhesion of polyurethane elastomers decreased with increasing the extent of fluorination in the poly mes.

Keywords:Perfluorinated Polyether;Mechanical Property;Blood Compatibility;Platelet Adhesion

[References]

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[1] Honeychuck RV, Ho T, Wynne KJ, Nissan RA, Chem. Mater., 5, 1299 (1993)

[2] Ho T, Wynne KJ, Macromolecules, 25, 3521 (1992)

[3] Takahara A, Jo NJ, Takamori K, Kajiyama T, "Progress Biomedical Polymers", eds. by C.G. Gebelein and R.L. Dunn, Plenum Press, New York (1990)

[4] Yoon SC, Ratner BD, Macromolecules, 21, 2392 (1988)

[5] Yoon SC, Ratner BD, Macromolecules, 19, 1068 (1986)

[6] Yoon SC, Sung YK, Ratner BD, Macromolecules, 23, 4351 (1990)

[7] Yu XH, Okkema AZ, Cooper SL, J. Appl. Polym. Sci., 41, 1777 (1990)

[8] Takakura T, Kato M, Yamabe M, Makromol. Chem., 191, 625 (1990)

[9] Takakura T, Kato M, Kataoka K, Okano T, Skurai Y, Transactions of the 3rd World Biomaterial Congress, 11, 423 (1988)

[10] Kashiwagi T, Ito Y, Imanishi Y, J. Biomater. Sci.-Polym. Ed., 5, 157 (1993)

[11] Imai Y, Watanabe A, Masuhara E, Jpn. J. Artif. Organs, 2, 95 (1973)

[12] Lyman DJ, Transp. Am. Soc. Artif. Organs, 18, 19 (1972)

[13] Kim HJ, Polym.(Korea), 25(1), 33 (2001)

[14] Lee HJ, Park KD, Han DK, Kim YH, Cho I, Polym.(Korea), 21(6), 1045 (1997)