This paper presents the impact of the addition of specific types of fatty acid derivatives on the lubrication properties of low sulfur diesel fuels. It discusses the most recent results, concerning the influence of adding low amounts of four specific types of biodiesel and two tertiary amides on the tribological behavior of the steel-on-steel systems, lubricated with low-sulfur automotive diesel. Experiments were carried out on the HFRR test rig. The obtained wear results have clearly shown a specific behavior of the components tested, which dissolved in selected base fuels at the concentration range of 0.05-10%. It is concluded that a very small amount of the selected biodiesel types and tertiary amides dramatically improves the low-sulfur diesel lubricity.