The aliphatic polyesters with high molecular weight have been prepared according to tno methods. First is the synthesis of the polyesters by polycondensation of dimethyl succinate (DMS) with 1,4-butanediol (BD) using various metal alkoxides as a catalyst. Among the metal alkoxides used, titanium tetraisopropoxide [Ti(OiPr)(4)] gate the best results (highest molecular weight and yield). Thus, we have prepared aliphatic polyesters using a variety combinations of diesters [MeOOC(CH2)(x)-COOMe, x = 2-8] with ED by the catalysis of Ti(OiPr)(4),. The polyesters with high number-average molecular weight (M-n > 35,000), except dimethyl adipate (DMA, x = 4)/BD polyester (M-n = 26,900), were obtained in high yield. The melting temperatures (T-m) of polyesters were relatively low (43.4-66.8 degreesC) except that (115.6 degreesC) of the DMS/BD polyester. Second is the synthesis of high molecular weight polyesters by chain extension reaction of lower molecular weight (M-n = 15,900-26,000) polyesters using hexamethylene diisocyanate (HDI) as a chain extender. The hi, values of chain-extended polyesters consequently increased more than two times (M-n = 34,100-56,000). The thermal properties of polyesters hardly changed before and after chain extension. Enzymatic degradations of the polyesters were performed using three different enzymes (cholesterol esterase, lipase B, and Rhizopus delemar Lipase) before chain extension. The enzymatic degradability varied depending on both thermal properties of polyesters [melting temperature and heat of fusion (crystallinity)] and the substrate specificity of enzymes, but it was the following order: cholesterol esterase > Lipase B > R. delemar lipase. The H-1-NMR spectrum of water-soluble degraded products of the polyester indicated that the polyester was degraded into a condensation product of diol with diester in a monomer form. The enzymatic degradation of chain extended polyesters was slightly smaller than that before chain extension, but proceeded steadily.