Biotechnology and Bioengineering, Vol.61, No.1, 61-67, 1998
High-throughput screening of historic collections : Observations on file size, biological targets, and file diversity
At Pfizer Central Research, high-throughput screening has been an important source of new leads for drug discovery for a decade. Our experience with over 150 high-throughput screens can address questions about necessary file size, how well particular biological targets fare (with particular reference to protein-protein interactions), and what file diversity means in practice.