The enantioselective esterification of racemic Ibuprofen with n-propanol by immobilized Mucor miehel lipase In supercritical carbon dioxide was studied. The enantiomeric excess of the product (sep) was 70 % at 15...20 % conversion. The enantioselectivity was faintly affected by temperature and the concentration of ibuprofen and lipase. The optimum temperature was 45 degrees C. The initial reaction rate increased with pressure, but enantioselectivity was not affected by pressure changes. The reaction rates In supercritical carbon dioxide at optimized conditions and in n-hexane were similar.