Isomerization of 1-hexene and cracking of n-hexane over HMCM-22 were carried out in a continuous flow glass reactor. The results were compared with those obtained over HZSM-5 under similar conditions of conversion. The catalyst HMCM-22 caused much more double bond shift and less skeletal isomerization in 1-hexene isomerization than HZSM-5. Also, in n-hexane cracking, HMCM-22 gave a higher yield of olefins and a lower yield of aromatics than HZSM-5. The results can be explained on the basis of the lower acidic strength and the inferior hydrogen transfer capacity of HMCM-22 compared to those of HZSM-5.