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Biotechnology and Bioengineering, Vol.71, No.2, 87-90, 2000
Solid-phase synthesis of 2,4-diaminoquinazolines
A highly efficient and versatile solid-phase synthesis of 2,4-diaminoquinazoline library from 2,4-dichloroquinazolines and amines using 3,5-dimethoxy 4-formyl-phenoxy-polystyrene resin is described.
Keywords:solid-phase synthesis;quinazolines;combinatorial chemistry;small molecule libraries;drug discovery