In the search for the active catalysts of hydrodesulfurization reaction, an attempt was made to use zeolites as supports. A series of NaLaX, Mo/NaLaX and NiMo/NaLaX as well as NaLaY, Mo/NaLaY and NiMo/NaLaY catalysts was prepared and their performance in this reaction was studied. It was shown that crystalline structure of the lanthana forms of the above zeolites only little collapsed after ion-exchange and impregnation with active Mo and NiMo components. The NiMo catalysts supported on the zeolites studied were found active in thiophene hydrodesulfurization. The catalysts with lanthana after the first step of ion exchange were the most active.