A thermodynamic insights based algorithm for integrated design and analysis of crystallization processes with electrolyte systems is presented. This algorithm consists of a thermodynamic calculation part, a process design/analysis part and a process simulation part, which are integrated through a calculation engine. The main feature of the algorithm is the use of thermodynamic insights, not only to identify and generate the feasible process alternatives, but also to obtain good initial estimates for the process simulation part, and for visualization of process synthesis/design. The main steps of the integrated system are illustrated through two case studies where one represents an industrial crystallization process.