This paper presents a two-degrees-of-freedom design methodology for interval process systems to guarantee both the robust stability and performance. For the robust stability issue, the design technique of Chen and Wang (1997) is utilized for searching a robust stabilizing feedback controller. Subsequently, a pre-filter is constructed based on using a frequency domain method to ensure the desired system performance. For illustration, the proposed design methodology is applied to design a robust control system for a second-order unstable plant in the presence of unknown but bounded parameter uncertainties. Simulation results reveal that the proposed scheme is effective and applicable for interval process systems.