For applications like the calibration of measuring instruments or the verification of measuring techniques, the production of sprays with predetermined, discrete polydisperse drop size spectra may be desired. Such sprays can only be achieved by means of drop production techniques which allow drops with a controllable size to be produced, e.g., the Rayleigh-type jet disintegration. Drop or spray generators working on the basis of this technique may be equipped with multihole nozzles for producing such discrete polydisperse sprays. The subject of the present paper is to provide the theoretical basis for the design of such a multihole nozzle according to a required drop size spectrum and liquid flow rate. Using the calculated design parameters, a multihole nozzle was manufactured and its performance verified experimentally. It was found that the design procedure developed works very well and the produced spray drop size spectra meet the requirements.