Reactive spray drying is a modern concept to produce highly dispersed powders out of a liquid solution. In contrast to the already established and industrially widely used spray drying, a chemical reaction occurs simultaneously in the liquid droplets beside the drying step. The main intention to combine the two steps of fabrication and processing in one multifunctional reactor is to gain tailor-made solid particles with controlled composition, shape and diameter from suspension in a single step. However, intensive research work is still necessary to analyze the numerous multi-phase phenomena in the reactive spray and to provide reliable measurement techniques which accomplish contactless high-speed high-resolution data collection inside the disperse spray. The present contribution is a first approach to achieve this goal by focussing on the development of simulation models for the reactor design on the basis of computational fluid dynamics (CFD) and basic criteria whether a chemical reaction is applicable for this special type of reactor.