Journal of Applied Polymer Science, Vol.82, No.5, 1187-1194, 2001
Development of a new silicone-base transdermal therapeutic system. II. Study of trifunctional ingredients
The effect of two trifunctional silicon compounds was investigated on the polarity behavior of silicone elastomers. by investigating the swelling properties in solvents of various polarity. The properties of the silicone elastomer were also influenced by methyltrimethoxysilane (MTS) and N-[(aminoethyl)aminopropyl]trimethoxysilane (GF-91) if they were used together with the networking agent. The cooperative effect of the polar liquid ingredients [glycerol, ethylene glycol, propylene glycol, poly(ethylene glycol) 400] and GF-91 as well as the dissolution of the liquid ingredients from the silicone elastomer were studied.
Keywords:polydimethylsiloxane;trifunctional ingredients;liquid additives;swelling properties;polarity