The hydrate phase boundary of a near critical fluid (NCF) was measured at 275-289 K in the presence of distilled water, synthetic formation water, and synthetic formation water with 10.41 wt. % methanol. The results agreed well with the predictions of an in-howe model, based on a cubic equation of state and statistical thermodynamics. To simulate a typical oil/gas production scenario the NCF was flashed at 298.1 K and 17.189 MPa, and the resulting liquid was subsequently flashed at 298.0 K and 4.089 MPa. Hydrate free zones of the resulting liquid fractions were measured to investigate the physical separation effect on the hydrate phase boundary. The in-howe thermodynamic model was used to simulate the separators conditions and to predict the hydrate free zone of the resulting liquid and the vapor fractions. The predictions agreed closely with the experimental data, demonstrating reliability of the thermodynamic model. The results also showed that the hydrate phase boundaries of the vapor and liquid phases, which resulted from physical separation, are similar to that of the NCF.