The kinetics of the ester-amide exchange in solution blends of the random liquid-crystalline polyester copoly(oxybenzoate-terephthalate) (P64) and polyamide 6 (PA6) were studied with carbon nuclear magnetic resonance. With second-order reversible reactions assumed, the activation energy of the ester-amide interchange in 30/70, 50/50, and 70/30 P64/PA6 blends were all about 24.0 kcal/mol. The pre-exponential factors for the ester-amide exchange in 30/70, 50/50, and 70/30 P64/PA6 blends were 2.01 x 10(11), 2.59 x 10(10), and 2.74 x 10(12) min(-1), respectively.