This paper presents the development and verification of a heat exchanger model for evaluating the thermal performance of an evaporator for a CO2 mobile air-conditioning system. The model has been developed, on the basis of the finite volume method, with emphasis placed on the air-side heat and mass transfer processes. The governing equations are derived from mass and energy balances using the newly developed air-side heat transfer and friction loss correlations for microchannel heat exchangers under both dry and wet conditions. The calculated air-side heat transfer and pressure drop data are in good agreement with measured data. However, the refrigerant-side pressure drop estimation for microchannel tubes usually underestimates the measured value. The simulation results and importance of selecting appropriate heat transfer and pressure drop correlations for the microchannel heat exchanger are addressed.