Good heating, ventilating and air conditioning (HVAC) control ensures comfort. It is usually also the most cost-effective way to improve energy efficiency of air-conditioned buildings. In this article, the comfort enhancement and energy saving potential with new control strategies are determined for the Human Science Building (HSB) at the University of Pretoria. A new software tool, QUICKcontrol, was used to perform the complex and fully integrated building, HVAC and control simulations. Various control strategies were investigated. These included air-bypass, reset control, setback control, improved start-stop times, economiser control and CO, control. The simulation models were firstly verified against measurements to ensure accurate and realistic retrofit simulations. It was then possible to ensure comfort and to predict savings of 60% in HVAC power consumption. This resulted in a simple payback period of 9 months. Preparing input data took about 2 days, while setting up the simulation model took another day. The typical run time for the fully integrated building, HVAC system and control simulation took approximately 90 s per day on an Intel(TM) Pentium 133 MHz personal computer.