The rate coefficient of the CH3C(O)O-2 + NO gas-phase reaction was measured over the temperature range of 218-370 K and total pressure of 2-5 Ton, using chemical ionization mass spectrometry detection of the CH3C(O)O-2 radical. The temperature-dependent expression for the rate coefficient was determined to be k(T) = (6.0 +/- 1.1) x 10(-12) exp{(320 +/-40)/T} cm(3) molecule(-1) s(-1), and a 298 K rate constant k(298) = (1.8 +/- 0.3) x 10(-11) cm(3) molecule(-1) s(-1) was found. These results quell some of the ambiguity presented by previous studies of this reaction and validate the recommended value to be used in tropospheric chemistry models.