The solubility of 1, 1, 1, 2, 2-pentafluoroethane (HFC125), 1, 1, 1, 2-tetrafluoroethane (HFC134a), 1, 1, 1-trifluoroethane (KFC143a) and 1,1-difluoroethane (HFC152a) in four well-known hydrocarbons have been measured at temperatures between 293.15 and 363.15 K and pressures between 0.05 and 2 MPa. Henry’s constant, and the activity coefficient for HFCs at infinite dilution, have been derived for measurements below 0.28 MPa. The measurements were made with an isochoric method and their uncertainty is less than 2% for Henry’s constant and less than 3% at high pressure. For several mixtures, the experimental data have been correlated with the UNIQUAC method and binary interaction parameters have been derived, resulting in a deviation from the data of less than 4%.