A set of nonbonded force field parameters consisting of atomic partial charges and van der Waals parameters has been derived by fitting experimental data for a broad set of organic compounds. The compounds in the fit spanned 11 functional groups: alcohols, aldehydes, amides, amines, carboxylic acids, esters, ethers, N-heterocycles, hydrocarbons, ketones, and sulfur compounds. The data consist of 136 crystal structures, 34 sublimation energies, and 63 gas-phase dipole moments. The nonbonded potential function is of the "9-6" form and is used in our class II CFF force field. This paper describes the fitting procedure and the quality of the fit as measured by comparing computed and experimental gas-phase dipole moments and crystal lattice energies. As a further test, each crystal structure was optimized. We report the accuracy of the computed crystal structures, including results obtained with force fields derived using two different combination rules. A summary is presented of the accuracy and consistency of predicted crystal lattice vectors and the lattice energies at the computed crystal structures. The results are discussed separately for each of the functional groups.