Nanoparticles of various dimensions of II-VI binary chalcogenides CdSe, PbSe, and Cu2-xSe, have been prepared by a very simple fast reaction between acetates or sulfates of Cd, Pb, and Cu and Na2SeSO3 in the presence of complexating agents, using microwave irradiation. The nanoparticles were analyzed by X-ray diffraction (XRD), electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS).