High silica hydrophobic FAU zeolite with perfect framework was prepared and used to study the interaction between the framework and 25 adsorbed organic compounds with TG/DTG/DTA, The compounds studied were hydrocarbons, alcohols, organic acids, chloro-containing organics, alkylamines, and esters. The saturating capacities of adsorption were measured. The affinity index A(T) was determined and used to evaluate the interaction between the framework of the zeolite and the adsorbates. Different A(T) value reveals unlike interaction. The Si-O-Si framework of the zeolite shows a stronger affinity with saturated hydrocarbons than with unsaturated ones, and usually phobic with the alkylalcohols and organic acids. The special sorbate/framework and sorbate/sorbate interactions for certain organics, such as amines, can be identified from the very high A(T) values, the double peaks in the DTG curves, and thermal effects in the DTA curves. The tendency of A(T) values for the adsorbed organic species on high silica hydrophobic FAU zeolite is similar to that on high silica hydrophobic MFI zeolite. An index of S-T, the adsorption density on the framework, is higher for MFI zeolite than for FAU zeolite, leading to the lower A(T) value of a certain adsorbate on FAU zeolite than on MFI zeolite.