Inorganic Chemistry, Vol.40, No.24, 6324-6327, 2001
Approaches to selective DNA binding in polyfunctional dinuclear platinum chemistry. The synthesis of a trifunctional compound and its interaction with the mononucleotide 5'-guanosine monophosphate
The introduction of the malonate ligand as a leaving group in trifunctional dinuclear platinum complexes allows stepwise binding modes to be controlled, as shown using a small mononucleotides such as guanosine 5'-monophosphate. Subtle changes in the metal coordination sphere can be used to produce specific and selective ternary DNA-DNA and DNA-protein interactions. [GRAPHICS]