Hydrogels based on n-alkyl methacrylate esters (n-AMA) of various chain lengths, acrylic acid, and acrylamide crosslinked with 4,4'-di(methacryloylmino)azobenzene were prepared. Swelling kinetics and the mechanism of degradation in vitro of the hydrogels as well as the mutual relations between both were studied by the immersion of slabs in buffered solutions at pH 7.4. The diffusion of water into the slabs was discussed on the stress-relaxation model of polymer chains. The results obtained agreed well with Schott's second-order diffusion kinetics. The gels are degradable by anaerobes in the colon. The results obtained showed that the degradation of networks proceeded via a pore mechanism. The factors influencing the swelling and degradation of the gels include the degree of crosslinking, the lengths of the n-AMA side chains, and the composition. These hydrogels have the potential for colon-specific drug delivery.