Chirally modified hectorites (laponite RD) were prepared by ion exchange with (R)- and (S)-N-alkyl-phenylethyl ammonium salts. The structure of the chiral clay-organocomplexes were studied by X-ray diffraction and FT-IR-spectroscopy. Due to the Low charge density of the laponite the organic modifiers lay on the inner surface of lamellae, no pillaring effect was observed. Using the chiral nanoreactors obtained in a catalytic process enantiodifferentiation was observed.