The results of the columnar mesomorphism (CM) prognosis and experimental data for the verification of a new series porphyrine derivatives (I a, b) are represented here. The calculation of molecular parameters (MP) for a known series porphyrins (I a - M = 2H, n=12, 16, 18; M = Zn or Cu, n = 16, 18) and others hypothetical structures is carried out on two algorithms. Some of hypothetical structures have been synthesized and their lyotropic and thermotropic mesomorphism has been investigated. The better correlation of the CM prognosis with experimental data has been found in case of new algorithm use, when all atoms of oxygen of near ester groups are included in the central part of a molecule.