The aqueous-phase catalytic dehydration of 2-propanol was investigated in a batch slurry reactor. Alumina, zeolite 13X, SAPO-5 and silicalite are all active in the liquid phase dehydration of 2-propanol at 463 K with silicalite being the most active catalyst. Propylene was found to be the major reaction product, with diisopropyl ether and acetone formed in trace amounts. The reaction kinetics over silicalite was determined at a temperature range of 434 to 463 K and at a concentration range of 4 to 10 mol% 2-propanol in water. A single site Langmuir-Hinshelwood-Hougen-Watson (LHHW) type mechanism was found to describe the kinetic data well. Water was found to inhibit the dehydration reaction. The activation energy over silicalite was determined to be 226.8 kJ/mol while the heat of adsorption for 2-propanol and water was -45.5 and -9.6 kJ/mol, respectively.