A new series of photocatalysts, In0.8M0.2TaO4 (M = Ni, Cu, Fe), were synthesized by a solid-state reaction and characterized by powder X-ray diffraction and Rietveld structure refinement. No apparent structural variation has been recognized with the change of doping atoms. However, the rate of H-2 evolution from Pt/CH3OH/H2O solution under UV irradiation significantly changed with the change of doping atoms. In0.8Ni0.2TaO4 showed much higher activity than the non-doped InTaO4 photocatalyst. Further-more, we found that under visible light irradiation (lambda > 420 nm) In0.8Ni0.2TaO4 exhibited also higher activity than the non-doped InTaO4 photocatalyst.