Silica-supported Rb2MoO4 and rubidium-promoted MoO3 were used as catalysts for the partial oxidation of propane in a fixed-bed continuous-flow reactor at 770-823 K using N2O as oxidant. The main hydrocarbon products of the reaction were propylene, ethylene, propanal and methane. Addition of various compounds of rubidium to the MoO3/SiO2 greatly enhanced the conversion of propane and promoted the formation of propanal at the expense of ethylene and propylene. The highest yield for the production of this compound was found over Rb2MoO4/SiO2 catalyst.